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Research in Kuroda Lab focuses on epigenetic regulation of gene expression with a concentration on understanding the interactions between epigenetic regulators and chromatin. The lab investigates complex genetic factors such as the MSL dosage compensation complex in fruit flies and the Polycomb Group in humans, as well as the BRD4-NUT oncoprotein involved in aggressive forms of squamous cell carcinoma. Recent findings include the discovery of nuclear foci containing BRD4-NUT protein that correspond to broad, cell type-specific hyperacetylated chromatin domains. These domains, termed ‘megadomains,’ exceed typical activated regions and involve extensive regulatory compartments surrounding oncogenes such as MYC and TP63, highlighting their critical role in the aggressive nature of NUT midline carcinoma. The lab employs innovative crosslinking strategies that allow detailed affinity purification and sequencing analysis, providing insights into the key epigenetic complexes that govern chromatin dynamics and gene regulation.