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Kyle Biggar is an Assistant Professor in the Department of Biochemistry at Carleton University. His current research focuses primarily on functional proteomics, which involves the discovery and characterization of proteins that coordinate their work to achieve specific cellular functions. This includes studying proteins that interact dynamically with enzymes to select substrates, and investigating the regulatory networks that influence protein signaling, especially in the context of disease progression and treatment resistance. Particular attention is given to post-translational modifications (PTMs), such as lysine methylation, which regulate protein-protein interactions and function. The lab employs advanced biochemical techniques and molecular biology to map enzyme-substrate interactions and investigate the binding preferences of interacting proteins. Research projects available for students include topics like the role of dynamic methylation in cellular adaptation to low oxygen and the expansion of enzyme-substrate networks for methyltransferase enzymes. Students will receive training in both basic and advanced cellular and biochemical methods, which foster interdisciplinary collaboration.
Includes MEng and MASc options.