Professor Dr. Lalita Ramakrishnan

Biography

Professor Lalita Ramakrishnan explores the pathogenesis of tuberculosis and the immune mechanisms behind it. Her research focuses on understanding the formation of granulomas, which are immune structures composed of macrophages and lymphocytes. Despite the development of antigen-specific immunity, mycobacterial infections can persist within these granulomas. Ramakrishnan has developed a zebrafish model to study the immune response to tuberculosis, utilizing the genetic similarities between Mycobacterium marinum and M. tuberculosis. This model allows for real-time monitoring of infection processes and the modulation of host and bacterial variables. Her research reveals crucial insights into host immunity and the strategies that pathogenic mycobacteria employ to evade immune responses. This work not only enhances understanding of TB pathogenesis but also aims to inform new intervention strategies.

Research Interests