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The Lambowitz Lab focuses on research related to group II intron-associated bacterial organellar reverse transcriptases (RTs) and their reverse transcription mechanisms. The laboratory employs a combination of genetic, biochemical, microbiological, and structural approaches, utilizing methods such as X-ray crystallography, cryo-electron microscopy (cryo-EM), and high-throughput RNA and DNA sequencing. Their research encompasses the analysis of human cellular, exosomal, and plasma RNAs, contributing to RNA diagnostics and liquid biopsy for human diseases. The lab is currently engaged in funded clinical trials and focuses on a variety of current research topics listed under their 'Research' section.
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