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The Lin Lab studies RNA modifications ('epitranscriptomics') in human health and disease. Their research focuses on post-transcriptional RNA processing modifications, which are key mechanisms in gene regulation and functional diversity in eukaryotic cells. The lab develops and applies high-throughput sequencing strategies and transcriptome engineering technologies to study the regulation and function of RNA modifications, alternative splicing, and m6A RNA methylation. They utilize state-of-the-art nanopore long-read sequencing platforms to discover and quantify diverse RNA species in both bulk tissues and single cells, comparing the full-length RNA transcripts between normal and diseased states, such as tumors and rare Mendelian disorders. The lab aims to discover molecular markers to develop RNA-guided diagnostics and therapeutics for diseases, especially focusing on RNA editing and its implications in various diseases, including neurological disorders and cancer.
Perelman School of Medicine, University of Pennsylvania • Philadelphia, PA
Responsible for teaching and conducting research in the fields of pathology and laboratory medicine.
Wharton Doctoral programs cover fields like Finance, Marketing, Management, and Operations, Information and Decisions.