Dr. Larry Fliegel

Biography

Larry Fliegel is a Professor in the Department of Biochemistry at the University of Alberta. His research focuses on the handling of acid problem organisms and the metabolism related to excess intracellular acid produced by cells. He investigates the deleterious effects of acid on enzyme activity related to the cell cycle and cardiac physiology. His laboratory primarily studies the regulation of intracellular pH, particularly the role of the sodium/proton exchanger (NHE1) in mammalian tissues. Fliegel’s work has significant implications in understanding heart disease, as the protein is critically involved in regulating cardiac function. His research includes examining the structure and activity of NHE1, utilizing site-specific mutagenesis to identify key amino acids for transport. He is also exploring the phosphorylation events impacting the localization and activity of this protein. With a particular interest in breast cancer, Fliegel's research aims to elucidate the mechanisms of metastasis and the role of ion movements in cellular processes. He is currently seeking high-quality personnel to join his team for ongoing projects in this area.

Research Interests

Experience