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Laura Denby is an ESAT Fellow at the University of Edinburgh, where she conducts research in the field of cardiovascular science. Her primary focus lies in investigating the role of non-coding RNAs in the regulation of injury and repair processes in the kidney and the cardiovascular system. With over five years of experience, she has developed expertise in small non-coding RNAs, specifically microRNAs (miRNAs) that are implicated in renal dysfunction and clinical translation pathways. Denby’s work has established the dysregulation of key miRNAs such as miR-214, miR-21, and the miR-29 family, which are critical in the context of renal fibrosis. She is currently exploring the potential of blockade strategies for these miRNAs using genetic and pharmacological agents, aiming to translate these findings into clinical applications. Additionally, her group has identified a miRNA signature that could serve as a non-invasive biomarker for disease severity in IgA nephropathy, indicating its potential application in assessing chronic kidney disease (CKD) progression. This signature represents a novel treatment-responsive biomarker that may facilitate rapid testing of new therapeutic interventions.
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