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Dr. Lauren Orefice is a researcher focused on the development, function, and dysfunction of somatosensory and viscerosensory systems. Her lab studies how somatosensory and viscerosensory circuits mediate tactile sensations and gastrointestinal functions. She is particularly interested in sensory experiences that begin in peripheral sensory neurons and how these influence the development of circuits in the spinal cord and brain. A central tenet of her work is exploring variations in sensory sensitivity and how individual experiences, influenced by genetic differences, contribute to the cognitive and social behaviors of individuals. Orefice’s research has uncovered that specific genetic mutations can alter the function of peripheral sensory neurons, contributing to symptoms observed in mouse models of Autism Spectrum Disorder (ASD). Her team investigates selective modulation of these neurons as a potential therapeutic approach to improve ASD-related symptoms. Employing a combination of genetics, anatomy, in vivo and in vitro electrophysiology, imaging, transcriptomics, and behavioral studies on mice, as well as investigations involving human-derived neurons, Orefice continues to expand the understanding of sensory processing disorders.
Orefice Lab • Exampletown, EX
Leading a research lab focused on the investigation of somatosensory and viscerosensory systems and their implications in sensory sensitivity and Autism Spectrum Disorder.
GRE is currently not required for the 2025-2026 cycle.