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Laurence C Eisenlohr is a Professor in the Department of Pathology and Laboratory Medicine at the Perelman School of Medicine at the University of Pennsylvania. His research expertise encompasses various areas of immunology, primarily focusing on MHC class I and class II-restricted antigen processing and presentation. Eisenlohr's work investigates the mechanisms of antigen presentation within cells and the implications for CD4+ and CD8+ T cell responses. He has made significant strides in understanding how different peptide sources, including those produced endogenously, are processed and presented to T cells. Additionally, his laboratory explores the generation of 'cryptic' epitopes that arise from errors in translation, further linking translation fidelity with immune response. His research also applies to cancer immunotherapy, particularly examining how specific fusion proteins can induce robust T cell responses in cancers such as papillary thyroid cancer. Through collaborative research, Eisenlohr seeks to advance therapeutic strategies that could enhance immune recognition of tumors, providing insights into the development of vaccines targeting cancer cells while maintaining immune tolerance to normal tissues.
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