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Lawrence Kazak is an Associate Professor in the Department of Biochemistry at McGill University. He obtained his PhD from the University of Cambridge in 2013. His research focuses on the mechanisms of mitochondrial energetics in health and disease. The Kazak lab combines mouse genetics with mass spectrometry and molecular cell biology to study the molecular control of mammalian energy metabolism. The lab's research is particularly concentrated on how metabolic pathways control mitochondrial energetics in adipocytes and cancer cells. His work involves the generation of novel genetically-engineered mouse models to accurately study cellular metabolism in vivo, particularly in adipose tissue, and aims to systematically examine the mechanisms supporting adipocyte energy expenditure by leveraging insights into brown fat thermogenesis. Kazak is also investigating the role of creatine metabolism in cancer, focusing on altered creatine metabolism associated with various cancers. The research questions posed by Kazak's lab include identifying the metabolic intermediates that control creatine-dependent thermogenesis and understanding how creatine regulates energy expenditure in adipose tissue. Addressing these questions is crucial for developing therapeutic strategies against obesity and cancer.
Department: Department of Medicine. Program: Experimental Medicine.