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Lee Wong completed his PhD at Monash University and began his post-doctoral work at the Murdoch Childrens Research Institute, which marked the beginning of his studies in chromosome biology. In 2012, he established his own laboratory, the Epigenetics Chromatin (EpiC) Research Laboratory, within the Department of Biochemistry and Molecular Biology at Monash University. His research focuses on identifying new epigenetic factors that regulate centromere and telomere function, with the aim of uncovering the mechanisms that control chromosome stability and genetic transmission, which are crucial for cell growth, tissue differentiation, and embryonic development. Recent studies from his group have identified frequent mutations in the histone variant H3.3 and its chaperone ATRX in human cancers, particularly in childhood brain cancers. His current research aims to define the normal functions of H3.3 and ATRX in controlling transcription and silencing telomeres throughout the genome while investigating the genome-wide epigenetic defects associated with H3.3 and ATRX mutations in cancers.
Monash University • Melbourne, Australia
Leads the Epigenetics Chromatin Research Laboratory focusing on chromosome stability and epigenetic regulation.
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