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Leo Spyracopoulos is a Professor in the Department of Biochemistry at the University of Alberta. He completed his Ph.D. at the University of Manitoba in 1996. His research program seeks to gain a deeper understanding of the biological functions of proteins, focusing on the determination of protein structures and the kinetics, dynamics, and thermodynamics of protein-ligand interactions. One of the primary tools utilized in his research is nuclear magnetic resonance (NMR) spectroscopy, which aids in revealing the mechanisms of protein ubiquitination at a molecular level. This fascinating area of study discusses how UEV-Ubc13 protein complexes facilitate the formation of non-canonical Lys-63 linked polyubiquitin chains, a process that is believed to play a crucial role in DNA repair and NFkB signaling pathways. His work underscores the importance of protein ubiquitination as a fundamental regulatory mechanism in eukaryotic cells, influencing various cellular processes. Additionally, his research emphasizes the non-proteolytic roles of protein ubiquitination, shedding light on its implications in cancer biology, particularly regarding its regulatory function in cell growth and DNA repair processes. Spyracopoulos has contributed significantly to the field, evidenced by his numerous publications in reputable journals such as the Journal of the American Chemical Society and the Journal of Biological Chemistry.
Department: Mechanical Engineering and Engineering Management