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Leonid Mirny combines biophysical modeling and analysis of large genomics data to address fundamental problems in biology. His group aims to understand how long DNA molecules, or chromosomes, are folded in 3D and how this 3D organization is utilized by living cells. Mirny's research led to the proposal of the DNA loop extrusion hypothesis, which has been experimentally confirmed and revolutionized our understanding of chromosomes in organisms. His work focuses on the physical mechanisms that regulate genes, repair DNA, and maintain epigenetic memory. Mirny collaborates directly with experimental scientists, and his students often co-advised with experimentalists contribute to experimental design, data analysis, and modeling.