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Lewis M. Brown is a Research Scientist at the Data Science Institute of Columbia University, associated with the Department of Biological Sciences. His work emphasizes the identification of proteins and their differential quantitative expression in various biological contexts, including cells, tissues, and biofluids. Utilizing advanced techniques such as mass spectrometry and affinity purifications, he tackles a wide array of research problems involving clinical samples, including those related to schizophrenia and traumatic brain injury, as well as diverse proteomes from bacteria, yeast, insects, and mammalian sources. His research also highlights the innovative use of new hardware and software capabilities in mass spectrometry, enabling state-of-the-art support for various research projects. Recently, he contributed to a position paper for the American Society for Biochemistry and Molecular Biology, discussing the forthcoming challenges in data handling within the field of proteomics, especially related to the vast amounts of information generated through data-independent scanning methodologies. This approach not only enhances the understanding of protein structures but also gives rise to large datasets requiring sophisticated analytical tools.
Department of Anthropology (GSAS)