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Lewis Chodosh is a Perelman Professor in the Department of Cancer Biology at the University of Pennsylvania. He holds an M.D. from Harvard Medical School and a Ph.D. in Biochemistry from the Massachusetts Institute of Technology. Chodosh's research primarily focuses on the mechanisms of cancer development and progression, with particular interests in tumor dormancy and recurrence. His laboratory employs genetically engineered mouse models and patient samples along with computational biology to study how breast cancers develop resistance to therapy, contributing to cancer mortality. He applies a diverse range of basic and translational research approaches to address fundamental clinical issues impacting cancer patients. His work encompasses understanding pathways regulating cancer development, metastasis, and the impact of obesity on cancer recurrence, as well as investigating the protective mechanisms of pregnancy against breast cancer. Chodosh's efforts also include using non-invasive imaging techniques to explore tumor biology. He works collaboratively in a lab environment with various graduate students and researchers focused on significant challenges in cancer biology.
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