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Li-Feng Jiang-Xie is an Assistant Professor in the Neuroscience Graduate Group at the University of Pennsylvania. He completed his Bachelor’s degree in Psychology and his Master’s in Brain Mind Sciences at National Taiwan University, followed by a PhD in Neurobiology from Duke University. His research specializes in elucidating the functions of sleep, particularly focusing on the self-cleansing brain hypothesis. Jiang-Xie's lab integrates a variety of experimental and computational techniques, including electrophysiology, two-photon imaging, and artificial intelligence, to explore the mechanisms through which sleep maintains metabolic homeostasis in the brain and its implications for neurodegenerative disorders. His recent work has unveiled significant insights into how neuronal activity during wakefulness drives the need for sleep and how sleep functions to clear metabolic waste. Jiang-Xie is pursuing innovative research directions, such as the dynamics of interstitial fluid during different brain states and the neural circuits responsible for fluid perfusion and molecular clearance.
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