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Liangcai Gu is an Associate Professor in the Department of Biochemistry at the University of Washington. He completed his B.S. at Lanzhou University in 1998, followed by an M.S. from Tsinghua University in 2002 and a Ph.D. from the University of Michigan in 2008. His research focuses on the development and use of integrated approaches for spatiotemporal, multimodal measurement and control of complex living systems at the molecular level. He has created protein-based sensors and actuators for chemical sensing, chemogenetic, and optogenetic manipulation of cell behaviors in living organisms. Furthermore, he developed polony gel-based spatial barcoding sequencing to spatially map single-cell transcriptomes and proteomes in morphologically intact tissues to study physiological, pathological, and pharmacological changes. Current projects involve studying cellular senescence in brain tissues, the mechanisms of chronic pain and addiction, and improving the safety and efficacy of gene and cell therapies.
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