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Dr. Lin Shen is an Assistant Professor in the Biological Sciences Division at the University of Chicago. His research focuses on autoimmune rheumatic diseases, which are a broad range of chronic illnesses that cause significant morbidity and mortality worldwide. Dr. Shen's laboratory investigates the critical role of T cell antigen receptor (TCR) recognition and signaling in the pathogenesis of autoimmune diseases. He aims to elucidate how altered TCR signaling strength affects immune tolerance and promotes autoimmunity, a topic that remains incompletely understood. By studying human monogenic diseases with known genetic defects linked to autoimmune phenotypes, Dr. Shen seeks to advance the understanding of disease pathogenesis in common polygenic autoimmune diseases. His work has implications for preventing adverse events related to cancer immunotherapy and for identifying new therapeutic targets for autoimmune diseases.
University of Chicago • Chicago, IL
Research and teaching in the field of immunology, particularly focusing on autoimmune diseases.
Department of Philosophy