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Dr. Lin Shen is an Assistant Professor at the University of Chicago, primarily focusing on autoimmune rheumatic diseases that are chronic illnesses causing significant morbidity and mortality worldwide. His research investigates the role of T cell antigen receptor (TCR) recognition and signaling in the pathogenesis of autoimmune diseases, particularly the effects of altered TCR signaling strength on immune tolerance and autoimmunity. Dr. Shen's laboratory aims to understand abnormal TCR signaling in human patients suffering from immune dysregulated disorders. The unique opportunity to study monogenic diseases with known genetic defects presents a way to advance knowledge on the pathogenesis of common polygenic autoimmune diseases. His studies have implications for preventing cancer immunotherapy-related adverse events and for the identification of novel therapeutic targets for autoimmune diseases.
Department of Philosophy