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Dr. Lin Shen is an Assistant Professor in the Department of Medicine at the University of Chicago. His research interests are focused on autoimmune rheumatic diseases, which encompass a wide range of chronic illnesses that lead to significant morbidity and mortality worldwide. A major aspect of Dr. Shen's work is investigating the crucial role of T cell antigen receptor (TCR) recognition and signaling in the pathogenesis of autoimmune diseases. He seeks to understand how altered TCR signaling strength affects immune tolerance and promotes autoimmunity, an area that remains incompletely understood. His laboratory studies human monogenic diseases with known genetic defects that manifest autoimmune phenotypes, providing insights into disease mechanisms applicable to common polygenic autoimmune diseases. These studies have implications for developing strategies to prevent cancer-related adverse events during immunotherapy and for identifying new therapeutic targets for autoimmune diseases.
Department of Philosophy