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Lina Dagnino's research focuses on skin biology and stem cells, with expertise in cellular and molecular biology and developmental genetics. The skin, as the largest organ of the body, serves several vital functions including protection against chemical and physical damage, microbial invasion, and prevention of dehydration and heat loss. Dr. Dagnino's lab investigates the mechanisms behind cellular decisions that maintain an undifferentiated, stem-cell phenotype and the pathways for terminal differentiation of keratinocytes in the epidermis. Her team is currently exploring the dynamics of normal regeneration, wound healing, and the roles of keratinocytes in cancer proliferation. In her state-of-the-art laboratory, trainees isolate and grow epidermal keratinocytes and melanocytes, employing gene therapy-like approaches to understand how these cells form, function, and maintain their stem-cell properties for tissue regeneration, while also examining their transformation into skin tumors.
Streams include Archaeology and Bioarchaeology, and Sociocultural Anthropology.