Dr. Linas Mazutis

Biography

Linas Mazutis develops cutting-edge single-cell technologies to dissect molecular mechanisms that create cell-to-cell variability and drive individual cell behavior and collective function. His research focuses on understanding the origins and consequences of cellular heterogeneity, which presents challenging tasks but also offers untapped opportunities for discovering new biological mechanisms and therapeutics. With advancements in single-cell -omics technology, his work allows for tackling cellular heterogeneity, discovering new cell types, and building comprehensive cell atlases of human organs. He has developed high-throughput single-cell technologies using semi-permeable capsules (SPCs), which can efficiently retain cellular mRNA and genomic DNA while enabling complex molecular biology workflows. His recent studies include applying SPC-based single-cell RNA sequencing in blood samples from acute myeloid leukemia patients, leading to a better understanding of the cellular heterogeneity in the disease. His work is aimed at further expanding the applications of these technologies to microbiology and biomedicine, focusing on identifying and characterizing low-abundance members of heterogeneous populations to advance the understanding of human health and disease.

Research Interests