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Linda Chelico is the Department Head of Biochemistry, Microbiology & Immunology at the College of Medicine, University of Saskatchewan. Her research specializes in understanding the role of host restriction factors in viral replication, particularly focusing on the APOBEC3 family of cytosine deaminases. Her lab investigates the mechanisms by which these enzymes inhibit the replication of retroviruses, such as HIV-1, by hypermutating viral genomes. Her research also explores the evolutionary significance of retrotransposons and endogenous retroviruses, as well as the relationship between these elements and cancer cell mutations. Chelico's work extends to the biochemical interactions of A3 enzymes with cellular and viral proteins, examining the interface of HIV-1 accessory proteins that facilitate the degradation of restriction factors. Her contributions have significant implications for understanding viral pathogenesis and the development of potential therapeutic strategies against viral infections and cancers.
University of Saskatchewan - College of Medicine • Saskatoon, SK
Leading the Department of Biochemistry, Microbiology & Immunology, overseeing research initiatives and academic programs.
Standard university-wide graduate requirements apply to most arts and science departments unless otherwise specified by the program.