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Professor Lindy Holden-Dye holds a personal Chair in Neuroscience at the University of Southampton. Her research interests focus on fundamental processes of neuronal communication, and she has established research expertise in invertebrate preparations. Her work contributes to important areas of neuroscience that inform understanding of mental health. Professor Holden-Dye's expertise in invertebrate neuroscience, particularly the nematode neural systems model organism Caenorhabditis elegans, positions her to participate in drug discovery and the mode of action programs for novel antiparasitics. Over decades, she has collaborated with industry to improve prospects for controlling parasitic nematodes. Her research group identified molecular targets for resistance-breaking anthelmintics, such as emodepside, highlighting its action through the calcium-activated K+ channel SLO-1, which brings about neuromuscular paralysis in nematode worms. This discovery has paved the way for new approaches in treating human filarial diseases. The experimental approaches deployed by her research group encompass genetics, whole animal physiology, and incorporate novel methods for tracking animal behavior and signal processing.
University of Southampton • Southampton, ENG, GB
Professor Lindy Holden-Dye has been leading research in the field of neuroscience, particularly focusing on invertebrate neuroscience and neuropharmacology.