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Lingjun Li is the Vilas Distinguished Achievement Professor at the University of Wisconsin–Madison, holding the Charles Melbourne Johnson Distinguished Chair in Pharmaceutical Sciences. His laboratory focuses on developing and implementing innovative mass spectrometry (MS)-based methodologies to address fundamental questions in islet biology, particularly in human and mouse pancreatic tissues. His research involves multi-faceted MS strategies for deeper analysis of human pancreatic islets in both healthy and diseased states. By utilizing techniques such as laser-capture microdissection coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS) and matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) imaging, his work aims to examine changes in proteomes, peptidomes, and post-translational modifications in pancreatic islets, achieving high spatial resolution and extensive biomolecular coverage. The long-term goal of his research is to improve current MS-based strategies for multiomic characterization of human pancreatic islets, significantly enhancing the understanding of human islet function and leading to the discovery of new therapeutic targets for Type 2 Diabetes and approaches involving stem-cell derived islet cells for Type 1 Diabetes.
Department: Department of Computer Sciences