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Linus Sandegren is a Professor at Uppsala University, specializing in Medical Biochemistry and Microbiology. His research primarily focuses on antibiotic resistance and its overall impact on public health. Within his domain, he explores the dynamics of plasmid-borne antibiotic resistance, studying fundamental aspects of how resistance plasmids are maintained and disseminated among pathogenic bacteria. Sandegren employs experimental systems that analyze clinically isolated multi-resistance plasmids, particularly those encoding extended spectrum β-lactamases (ESBLs) found in enteric bacteria such as Escherichia coli and Klebsiella pneumoniae. His main themes of interest include investigating the impact of low levels of antibiotics on the spread and selection of multi-resistance plasmids, the fitness costs associated with plasmid carriage, and the dynamics of gene amplification in response to treatment. The outcomes of his research aim to enhance knowledge of bacterial evolution and resistance mechanisms, ultimately informing antibiotic treatment strategies to curb the emergence of new resistances.
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