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Dr. Ivashkiv joined the faculty of the Hospital for Special Surgery and Weill Cornell Medical College in 1992 and currently serves as the Chief Scientific Officer. A Professor of Medicine specializing in Immunology, his research focuses on cytokine-mediated pathogenic mechanisms involved in autoimmune and inflammatory musculoskeletal diseases. His laboratory emphasizes the regulation of cytokine signaling, gene transcription, and the epigenomic mechanisms that contribute to inflammatory phenotypes in myeloid cells, osteoclasts, and synovial fibroblasts, which are critical in conditions such as rheumatoid arthritis and systemic lupus erythematosus. He has significantly advanced our understanding of the Jak-STAT signaling pathway in rheumatoid arthritis and explored mechanisms of inflammatory bone resorption. Dr. Ivashkiv employs innovative methodologies, including transgenic approaches and CRISPR-Cas9 genome editing, to investigate the regulation of human autoimmunity-associated genes. His long-term research goals include identifying targeted therapies for inflammatory autoimmune diseases, integrating both basic science and translational research to provide tailored treatments for patients.
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