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Dr. Liron Bar-Peled is an Assistant Professor in the Department of Medicine at Harvard Medical School and a member of the Cancer Center at Massachusetts General Hospital. His research focuses on metabolic adaptability in cancer cells, exploring how they rewire core metabolic networks to sustain rapid growth and how byproducts like reactive oxygen species (ROS) influence cellular functions. Through decades of research, Dr. Bar-Peled has uncovered the role of ROS as dynamic signaling molecules that can regulate protein functions. He studies the NRF2/KEAP1 pathway as a master regulator of cellular antioxidant responses, particularly in lung cancers, and aims to identify novel regulators of this pathway using proteomic and genomic methodologies. His lab's work is pivotal in revealing co-dependencies and potential therapeutic targets within transcription factor signaling pathways that are altered in cancer metabolism.
Harvard Medical School • Charlestown, MA
Exploring metabolic adaptability in cancer cells and investigating novel therapeutic targets.
Administered by the Harvard Kenneth C. Griffin Graduate School of Arts and Sciences (GSAS).