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Lisa Cirillo is an Associate Professor and Assistant Dean of the Basic Science Curriculum at the UW Comprehensive Diabetes Center, UW–Madison. Her research primarily focuses on the roles of FoxO and FoxA transcription factors in liver development and metabolic processes. Her laboratory has shown the importance of interdependent chromatin binding and remodeling by FoxO1 and FoxA in maintaining an active chromatin environment, which is essential for the expression of insulin-regulated genes in the liver. Using ChIP-Seq data, her research highlights how these factors co-target multiple insulin-regulated genes involved in glucose, lipid, and cholesterol metabolism. Current studies aim to confirm the regulation of co-targeted genes in hepatocytes, identify accessory proteins that are co-recruited with FoxO1 and FoxA, and investigate the cooperation of these proteins in the activation of insulin-regulated genes. Understanding these regulatory mechanisms is crucial, as disruptions are likely contributors to metabolic disorders such as diabetes.
Department: Department of Computer Sciences