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Dr. Lisa M. Frenkel is a Joint Professor and Director of HIV Drug Resistance Assays at UW Medicine. Her research focuses on translational basic laboratory research related to HIV drug resistance and persistence. The Frenkel Group is known for their pioneering investigations in the dynamics of HIV drug resistance reservoirs and how pre-treatment drug resistance influences outcomes for patients receiving antiretroviral therapy. The lab has collaborated with the NIH's International Maternal Pediatric Adolescent AIDS Clinical Trials network as the primary HIV-DR genotyping lab, contributing significantly to international HIV studies. Dr. Frenkel has been involved in innovative studies that examine the mechanisms behind HIV persistence during effective ART and has introduced novel concepts into the field, including the identification of clonal populations of HIV-infected cells. Her current projects include investigating the effects of HIV on cervical dysplasia in Ugandan women and studying the differences in HIV reservoirs among South African children and their mothers. Dr. Frenkel's contributions emphasize the importance of developing economical assays and understanding how drug resistance affects maternal-to-child transmission of HIV.
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