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The Maves Lab at the University of Washington focuses on skeletal muscle and heart development, contributing to new understandings of treatments for muscular dystrophy and heart disorders. Utilizing zebrafish as an animal model due to their advantages in genetic manipulation, in vivo imaging, and drug screening, the lab explores the origins of heart and muscle disease through genetic and embryonic studies. Current projects include using zebrafish to model Duchenne muscular dystrophy, identifying drug therapies for the disease, investigating mechanisms of skeletal muscle fiber-type differentiation, and employing CRISPR genome screening to engineer mutations for genes implicated in congenital heart defects. These research efforts aim to uncover complex genetic interactions affecting heart and muscle development.
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