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Lisa Steiner is a Professor Emerita specializing in Immunology at the Massachusetts Institute of Technology. Her research predominantly focuses on analyzing the zebrafish genome to understand the role of white blood cells in the immune system. Throughout her illustrious career, she has explored the structural variation of antibodies across different vertebrate species, demonstrating that effective antibodies share fundamental features in their variable and constant regions while exhibiting unexpected structural diversity. Her findings indicate that non-mammalian vertebrate polypeptide chains often fall into classifications that were primarily developed for mammalian antibodies, such as kappa, lambda, and gamma. This work reflects the concept of 'evolutionary tinkering' as articulated by Francois Jacob, highlighting the extensive variability present in the immune system of various species.