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Lisheng Zhang is an Associate Professor in the Department of Medicine at Duke University, specializing in the pathogenesis of vein graft neointimal hyperplasia and atherosclerosis. His research focuses on developing and characterizing an interposition vein graft model in mice, which allows exploration of the gene products contributing to vein graft disease. His work utilizing carotid artery transplants in congenic mice has demonstrated that neointimal cells in vein grafts originate from specific cellular pools at the time of implantation. Zhang's studies indicate that the expression of tumor necrosis factor receptor-1 in vein graft cells significantly contributes to the pathogenesis of neointimal hyperplasia, an important factor affecting treatments for vein graft disease. Furthermore, he has worked on surgical models to investigate the arterial wall's role in atherosclerosis. His ongoing projects examine the influences of inflammatory cytokine receptors on neointimal hyperplasia and atherosclerosis, alongside planned extensions of his research into surgical models involving mice.
Duke University • Durham, NC
Associate Professor of Medicine with a focus on vascular biology and pathology.
Duke University • Durham, NC
Assistant Professor of Medicine with a focus on research in vein graft pathology.
Department of Biomedical Engineering (MS program)