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Lorena Sue Beese is a James B. Duke Distinguished Professor of Biochemistry at Duke University, leading research focused on understanding biological processes at atomic detail. Her multi-disciplinary strategy involves the use of macromolecular X-ray crystallography and cryo-electron microscopy to produce high-resolution, three-dimensional images of proteins and their complexes. Professor Beese's work has significantly advanced knowledge in enzyme mechanisms, particularly through her studies of DNA polymerases and repair enzymes, elucidating molecular mechanisms crucial to maintaining genomic stability. Her lab also investigates structural biology related to protein prenyltransferases, aiming to develop inhibitors for cancer treatment. Beese has contributed to significant insights regarding structural determinants for substrate specificity in lipid-modifying enzymes and has made strides in the design of therapeutics targeting pathogenic fungi and neurodegenerative diseases. She has a strong publication record and has secured numerous grants aimed at elucidating the complex mechanisms of DNA repair and enzyme functions, making her a prominent figure in the field of structural biology and biochemistry.
Duke University • Durham, NC
Leading research, teaching, and mentoring students in Biochemistry.
Duke University • Durham, NC
Conducted research and taught courses in Biochemistry.
Duke University • Durham, NC
Engaged in research and education in the field of Biochemistry.
Department of Biomedical Engineering (MS program)