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Lori T Raetzman is a Professor in the Neuroscience Program with extensive research in neuroendocrine systems. Her work primarily focuses on hypothalamic neuron development and homeostatic endocrine systems. She investigates the critical roles of the hypothalamus in body homeostasis, essential processes such as feeding, growth, and reproduction, and how hormonal disruption can lead to obesity, infertility, and dwarfism. Her research employs genetic techniques involving transgenic and knockout mice to understand the Notch signaling pathway's role in the development of hypothalamic progenitor cells. Additionally, she collaborates with the Underhill lab to explore the impact of maternal environments and exposure to endocrine-disrupting chemicals on hypothalamic progenitors, aiming to define normal signaling mechanisms that dictate stem cell fate in the hypothalamus. The ultimate goal of her studies is to identify causes of congenital neuroendocrine disorders and develop strategies for neuronal engineering to address damaged developmental pathways.
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