Dr. Lothar Schermelleh

Biography

Lothar Schermelleh is a professor at the University of Oxford specializing in Biochemistry. His research focuses on understanding the relationship between 3D nuclear organization and genome activity in mammalian cells, utilizing a combination of genetic tools and advanced optical imaging methods. As an affiliated member of the Micron Advanced Bioimaging Unit, he is involved in the development of computational analysis and fluorescence labeling tools for super-resolution microscopy. His biological research aims to uncover the interplay of biophysical forces and epigenetic memory within the cohesin complex, which modulates cell-type specific transcriptional programs, contributing to processes such as cell differentiation and pathological states. His research group employs a combination of genetic editing techniques and cell biological manipulations, coupled with innovative live-cell correlative super-resolution imaging analysis approaches, to enable direct observation of genome activity, transcription, replication, and repair within the context of the nuclear environment at the nanoscale.

Research Interests