Dr. Louise Boyle

Biography

Professor Louise Boyle is an established expert in Molecular Immunology at the University of Cambridge, leading a research group within the Department of Pathology. Her work focuses on the molecular mechanisms that control peptide selection for immune recognition. Central to her research is the Major Histocompatibility Complex (MHC) class molecules, which play a pivotal role in orchestrating the immune system's response to tumors and pathogens. Over the past decade, she has characterized the role of TAPBPR, a novel MHC class specific component involved in antigen processing and presentation. TAPBPR acts as a peptide editor, refining the antigen repertoire displayed for immune recognition. Her laboratory has uncovered critical insights into the mechanistic functions of TAPBPR, including its role in peptide dissociation from MHC-I molecules and its involvement in facilitating the glucosylation of MHC-I proteins, enhancing their recycling within the peptide loading complex. These significant findings suggest that TAPBPR can be utilized therapeutically, particularly in immunogenic peptide decoration of cells, thus offering new avenues for cancer treatment.

Research Interests

Experience