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Loyal Goff is an Associate Professor in the Solomon H. Snyder Department of Neuroscience at Johns Hopkins University School of Medicine. He researches the transcriptional landscape of embryonic and postnatal cells, particularly in the developing mouse retina. His work emphasizes the significance of cell-to-cell variation and heterogeneity in cellular functions and responses, which have often been masked in aggregate experimental designs. Goff's lab utilizes advanced technologies to probe physiological and genomic states of individual cells, thereby enhancing the understanding of cellular responses and the impact of genetic variations in disease contexts. His research interests extend to characterizing cellular diversity within the mammalian central nervous system, studying population-level responses to stimuli, and analyzing how genetic variation influences cellular diversity in both steady-state and disease conditions. Goff's ultimate aim is to elucidate the processes underlying neuronal plasticity and developmental fate specification, as well as the effects of disease-associated mutations on the organization and function of the mammalian brain.
Johns Hopkins University School of Medicine • Baltimore, MD
Teaching and conducting research in the field of neuroscience, focusing on cellular diversity and transcriptional analysis.
Department of Biomedical Engineering (PhD). Focus areas: Biomedical Data Science, Computational Medicine, Genomics, Imaging, Immunoengineering, Neuroengineering.