Dr. Luca Fusi

Biography

Luca Fusi obtained his PhD in Physiology from the University of Florence, Italy, where he investigated the structure-function relationship of molecular motors in skeletal muscle using techniques such as small-angle X-ray diffraction. He joined King’s College London in March 2010 as a post-doctoral fellow. In 2014, he received the King’s Prize Fellowship to study novel regulatory mechanisms of skeletal muscle contractility based on myosin filament dynamics. He was awarded the Sir Henry Dale Fellowship from the Wellcome Trust and Royal Society in 2018 to establish a laboratory at the Randall Centre for Cell and Molecular Biophysics, focusing on cardiac muscle. His laboratory employs mechanical and structural methods, including fluorescence polarisation microscopy, to explore the molecular mechanisms controlling force generation in striated muscle at cellular and subcellular levels. His research interests encompass thick and thin filament mechanisms of contraction regulation in human cardiac and skeletal muscle, as well as the molecular basis of length-dependent activation in cardiac muscle. Additionally, he studies the alterations associated with aging and disease in muscle function.

Research Interests

Experience