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Luca Pinello is an Associate Professor in Pathology at Harvard University. He is a computational biologist focused on understanding the role of chromatin structure and dynamics in gene regulation, specifically in relation to non-coding regions such as enhancers, promoters, and insulators. His research integrates omics data to explore the functional mechanisms of the non-coding genome, facilitating the development of innovative computational tools for the community. Pinello's work emphasizes the development of methodologies that apply cutting-edge experimental assays, including single cell genome editing, to analyze genetic and epigenetic variation affecting gene regulation in human traits and diseases. His lab has pioneered computational frameworks such as HAYSTACK and CRISPResso, which have become standard tools for assessing outcomes in genome editing experiments. Additionally, he is actively involved in the Human Cell Atlas initiative, working on single-cell trajectory analysis to model gene expression variability and the interplay between chromatin and DNA methylation.
Administered by the Harvard Kenneth C. Griffin Graduate School of Arts and Sciences (GSAS).