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Lucie Delemotte's research focuses on understanding, predicting, and modifying membrane protein function. Membrane proteins are essential for cellular operations, enabling cells to adapt to environmental changes such as the presence of hormones or drugs and fluctuations in ionic concentrations. The function of these proteins is largely defined by their structure, particularly their three-dimensional shape. Recent discoveries indicate that the dynamic properties of protein structure also play a significant role in determining function. Her lab conducts molecular dynamics simulations of membrane proteins, including ion channels, G-protein coupled receptors, and solute transporters, to elucidate how these proteins respond to various stimuli. The lab aims to resolve the movement of proteins in response to different stimuli through regular simulations and enhanced sampling protocols, enabling the collection of trajectory data over longer time scales. The noisy data generated from these simulations is analyzed using dimensionality reduction and clustering techniques, leading to the development of mechanical models of protein function. Malfunction of membrane proteins is linked to diseases such as epilepsy, cardiac arrhythmias, and cancer, making their characterization crucial. The Delemotte lab is also engaged in developing methods to design new modulators that can elicit desired effects through novel modalities.
KTH Royal Institute of Technology • Stockholm, Sweden
Leading research in understanding and modifying membrane protein functions.
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