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Lucy MacDonald is a post-doctoral research assistant currently working on synovial tissue macrophage heterogeneity, their development, function in healthy states, and their involvement in Rheumatoid Arthritis (RA) inflammation and disease resolution. She graduated with a PhD in Immunology from the University of Glasgow in December 2022, supported by a studentship from the Research Inflammatory Arthritis Centre Versus Arthritis (RACE) consortium, under the mentorship of Professors Mariola Kurowska-Stolarska and Thomas Otto. Her research focuses on understanding macrophage development and functional specialization defined by their niche in various tissues such as synovium, skin, lung, and heart, particularly during different disease states. By utilizing techniques like single-cell transcriptomics and spatial sequencing, she investigates the interactions between distinct macrophage subsets and the tissue microenvironment. Her work has identified specific synovial tissue macrophage phenotypes responsible for disease initiation and resolution in RA, highlighting factors that influence macrophage homeostasis and immune regulation.
University of Glasgow • Glasgow, Scotland
Currently investigating macrophage heterogeneity and their roles in health and disease.