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Luigi Margiotta-Casaluci is a Senior Lecturer in Toxicology at King’s College London, specializing in comparative pharmacology and toxicology. His research focuses on understanding multi-scale mechanisms underlying chemical-induced toxicity and developing innovative approaches to predict potential adverse effects of chemicals on humans and wildlife. The Margiotta-Casaluci Lab integrates computational biology, network biology, and zebrafish models to address critical research questions related to human and environmental health. He is internationally recognized for his expertise in applying the Adverse Outcome Pathway (AOP) framework to synthesize evidence and assess biological causality within toxicological pathways. His current research emphasizes alternatives to animal testing, with a strong commitment to advancing fish-specific New Approach Methodologies (NAMs) that aim to reduce reliance on live fish testing. A significant area of interest in his lab includes investigating causal relationships between drug and chemical-mediated pro-inflammatory responses and the manifestation of adverse health outcomes, particularly behavioral alterations. He collaborates with industry partners and advises scientific governmental agencies on integrating toxicology concepts to protect environmental and human health. In 2022, he was appointed as an Early Career Researcher Member of the UK Hazardous Substances Advisory Committee (HSAC), providing expert advice on protecting the environment and human health from potentially hazardous substances.
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