Dr. Luke Jostins

Biography

Luke Jostins is a Sir Henry Dale Fellow at the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford. His research is primarily focused on statistical genetics and immune variation, particularly in the context of identifying genetic associations related to inflammatory bowel disease (IBD). Jostins has successfully employed statistical techniques to understand the function of genetic risk variants and their implications in various complex diseases involving the immune system. He emphasizes the shared nature of risk variants across multiple immune diseases, contributing to a deeper understanding of immune pathways and their expression in relevant immune cells, including monocytes and CD4 T-cells. His work involves significant collaborations with statistical geneticists, molecular biologists, and immunologists to unravel the complex interactions between genetic risk and human immune pathways. By analyzing large-scale medical cohort data with advanced computational techniques, he aims to identify multi-gene signatures that underscore immune variations influencing health outcomes. Additionally, he collaborates with cell biologists and clinical researchers to innovate methods for profiling the immune system in relation to specific pathways linked to chronic diseases.

Research Interests