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Dr. Luke McCaffrey is an Associate Professor in the Department of Oncology at McGill University. His laboratory investigates the mechanisms of cell polarity in epithelial morphogenesis and cancer progression, particularly focusing on stem cell renewal. Dr. McCaffrey's research areas include the role of specific protein complexes in tumor initiation, growth, invasion, and metastasis. The laboratory uses advanced techniques such as time-lapse confocal microscopy and 3D organotypic cultures to study the dynamics of cell behavior in mammary tissue. His findings underscore the critical role of epithelial polarity organization in cancer biology, especially in breast and ovarian cancer, and how disruptions in these processes can lead to malignant transformation. He employs various model systems, including mouse models and human tissue samples, to elucidate the relationship between cell signaling and cancer progression. Dr. McCaffrey's contributions to the field have significant implications for understanding the cellular mechanics underlying cancer development and providing insights into potential therapeutic targets.
Department: Department of Medicine. Program: Experimental Medicine.