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Lynn Raymond combines neuroscience research with clinical practice in Neurology. His lab investigates the pathogenic mechanisms behind Huntington's disease, focusing on glutamate receptor structure-function and modulation of signaling. Working with Huntington's disease mouse models, he has made significant contributions in altering striatal neuronal NMDA-type glutamate receptor trafficking and excitatory synaptic signaling. This research is central to understanding the mechanisms behind early striatal dysfunction. The lab has concentrated on early changes in cortical-striatal signaling and cortical pyramidal glutamatergic synaptic plasticity, which contribute to impairments in learning and cognitive flexibility, promoting selective neuronal degeneration. Additionally, Raymond's lab developed an automated home-cage system to assess motor learning, employing electrophysiological and optogenetic approaches to study cortical-striatal activity in awake behaving mice, allowing for the determination of circuit changes underlying Huntington's disease. He has also served as the President of the Canadian Association for Neuroscience and is the Director of the Huntington's Disease Medical Clinic at UBC, actively practicing as a neurologist.
Offers course-only and thesis routes. Focus areas include philosophy of science, mind, ethics, and Asian philosophy.