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Mahesh P. Gupta is a professor in the Biological Sciences Division at the University of Chicago. His primary research focus is on heart failure and the molecular mechanisms involved in its pathology. His laboratory investigates the roles of chromatin remodeling enzymes, particularly sirtuins, in the regulation of muscle gene expression and cellular senescence related to cardiac hypertrophy and fibrosis. Gupta's work highlights the significance of various genes in maintaining normal heart function and aims to understand how alterations in these genes contribute to heart failure. He has also explored how sirtuins interact with mitochondrial proteins to regulate cardiac function under physiological stressors such as diabetes and obesity. His extensive research includes numerous publications that discuss mechanisms of heart disease and the fundamental roles played by sirtuins and other regulatory enzymes. Gupta's academic credentials include MS and PhD degrees in Physiology and Pharmacology from the All India Institute of Medical Sciences, New Delhi, and post-doctoral training in cardiac cell biology at the University of Chicago. He has received several awards for his contributions to cardiac research, including fellowships from the American Heart Association and recognition for his scientific leadership in the field.
University of Chicago • Chicago, IL
Teaching and conducting research in the field of cardiac biology and physiology.
Department of Philosophy