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Dr. Mahesh P. Gupta is a Professor and Director of the Basic Cardiothoracic Surgery Research Program at the University of Chicago. His research primarily focuses on the molecular mechanisms underlying cardiac dysfunction and the development of heart failure. With a solid academic foundation that includes a Master of Science and a Ph.D. from the All-India Institute of Medical Sciences in New Delhi and post-doctoral training at the University of Chicago, Dr. Gupta has contributed significantly to the understanding of heart failure over the past decades. His laboratory aims to elucidate the complex cellular and molecular pathways involved in heart disease. Current projects in his lab include investigating the PARP-SIRT1 axis in heart failure development, exploring ways to activate sirtuins to prevent adverse cardiac remodeling after myocardial infarction, mitigating the cardiotoxic effects of anti-cancer drugs, and understanding the role of sirtuins in aging-related cardiac and skeletal muscle diseases. Dr. Gupta is also actively involved in committees on Cellular Molecular Physiology and Molecular Medicine at the university, reflecting his commitment to the advancement of cardiac research and education.
University of Chicago • Chicago, IL
Director of the Basic Cardiothoracic Surgery Research Program, leading research initiatives in cardiac health.
Department of Philosophy