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Mahesh Gupta is a professor of cardiac surgery at the University of Chicago, focusing on the molecular basis of heart failure and the role of chromatin remodeling enzymes in muscle gene regulation and cellular senescence. His research also examines how these mechanisms contribute to cardiac hypertrophy and fibrosis. Gupta studies the pathological state of heart failure, where the heart's ability to pump blood is compromised due to defects in myocardial contraction. He emphasizes the importance of understanding chromatin structure, particularly how histone deacetylases, acetyltransferases, and sirtuins influence cardiac function under various stressors, including obesity, diabetes, and aging. His educational background includes an MS and PhD in Physiology and Pharmacology from the All India Institute of Medical Sciences, with post-doctoral training at the University of Chicago. He has received several honors throughout his career, including being a Fellow of the American Heart Association and recipient of the Vincenzo Panagia Distinguished Lecture Award from the University of Manitoba. Gupta is a principal investigator for multiple NIH-funded projects aimed at improving recovery post-surgery in failing hearts and exploring protective mechanisms in diabetic hearts. His laboratory is dedicated to unraveling the complex interactions between genetic expressions and heart disease to identify new therapeutic targets.
Department of Philosophy