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Malin Lindqvist Appell is a Senior Associate Professor at Linköping University with a primary research interest in pharmacogenetics and thiopurine metabolism. Her work focuses on understanding how genetic differences impact drug metabolizing enzymes and their effects on patients' responses to medication. There are significant variations in enzymatic activity levels within the population, largely due to single nucleotide polymorphisms (SNPs) of the genes responsible for encoding these enzymes. Appell is dedicated to finding new ways to minimize the side effects of anticancer treatments, particularly through the application of thiopurines for conditions like acute lymphoblastic leukemia in children and inflammatory bowel diseases in adults. A crucial enzyme in thiopurine metabolism is thiopurine methyltransferase (TPMT), which varies in activity across the population. With a collaborative effort through the TPMT nomenclature committee, she is engaged in mapping and naming genetic variants impacting this gene, contributing significantly to personalized treatment approaches. Her research also utilizes cancer cell lines as vital tools to investigate the genetic regulation and response to drug treatments relevant to thiopurine metabolism.
Linköping University • Linköping, Sweden
Conducting advanced research in pharmacogenetics and thiopurine metabolism.
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